Mevalonate kinase Antibodies

AND MVK ELISA kits, Mevalonate kinase Proteins

Many biological assays use antibodies to detect Mevalonate kinase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Mevalonate kinase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Mevalonate kinase antibodies...

We validate the specificity of these antibodies to Mevalonate kinase by testing them on tissues known to express MVK positively and negatively. Browse below to find the MVK antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Mevalonate kinase? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the MVK IHC Guide

MVK Infographic by Boster Bio

All MVK Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-MVK Antibody Picoband®

Western blot analysis of MVK using anti-MVK antibody (A02465-2)

IHC analysis of MVK using anti-MVK antibody (A02465-2)

Human

ELISA, Flow Cytometry, IP, IF, IHC, WB

$370
Cat # A02465-2
100 μg/vial

Mevalonate Kinase Colorimetric Cell-Based ELISA

Western blot analysis of extracts from COS7/COLO205 cells

Human

ELISA

$480
Cat # EKC1772
1 kit, containing one 96-well plate and all necessary reagents

MVK (NM_000431) Human Over-expression Lysate

MVK Human Over-expression Lysates NM_000431

Human

$628
Cat # LS004598
20 µg, 100 µg

Anti-MVK Rabbit Monoclonal Antibody

Western blot analysis of MVK expression in HepG2 cell lysate

Human

Flow Cytometry, WB

$370
Cat # M02465-1
100 μl/vial

MVK (NM_000431) Human Recombinant Protein

Coomassie blue staining of purified MVK protein

$1249
Cat # PROTQ03426
20 µg

MVK Overview

Facts about Mevalonate kinase.

MVK 3D structure. Source: alphafold

Mevalonate kinase (MVK)

Catalyzes the phosphorylation of mevalonate into mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:9325256, PubMed:18302342). .

Gene Information

Human
Gene Name:	MVK
Uniprot:	Q03426
Entrez:	4598

Family

Belongs to:

GHMP kinase family

Alternative Names

EC 2.7.1.36; LH receptor mRNA-binding protein; LRBP; mevalonate kinase (mevalonic aciduria); mevalonate kinase 1; mevalonate kinase; Mevalonic Aciduria; MKFLJ96772; MVK; MVLK; POROK3

Molecular Weight

Mass (kDA):
42.451 kDA

Genomic Context


Human

Location:	12q24.11
Sequence:	12; NC_000012.12 (109573461..109598125)

Subcellular Localizations

Cytoplasm. Peroxisome.

Diseases

Familial Mediterranean Fever
Deficiency Of Mevalonate Kinase
Hyper Igd Syndrome
Hypergammaglobulinemia
Relapsing Fever
Brucellosis
Mevalonic Aciduria
Inflammation
Carcinogenesis
Malignant Neoplasms
Neoplasms

Pain
Hereditary Autoinflammatory Diseases
Abdominal Pain
Exanthema
Arthralgia
Malignant Paraganglionic Neoplasm

Interacting Proteins

POT1

Pathways

Pathogenesis
Cell Proliferation
Immune Response
Translation
Regeneration
Cell Death
Excretion
Secretion
Transport
Innate Immune Response
Cell Killing
Luteinization
Cholesterol Homeostasis

Keratinization
Cell Activation
Cellular Senescence
T Cell Activation
Aging
Cytokine Secretion
Oxidative Phosphorylation

PTMs

Oxidation
Phosphorylation

Amidation
Geranylgeranylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MVK

References

PMID: 1377680 by Schafer B.L., et al. Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.

PMID: 8302606 by Graef E., et al. Insertional activation of mevalonate kinase by hepatitis B virus DNA in a human hepatoma cell line.